Enhancement of Chemically-Induced HL-60 Cell Differentiation by 3,3'-Diindolylmethane Derivatives
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of c-myc during chemically induced differentiation of HL-60 cultures.
Previous studies have demonstrated both an elevated level of cellular myc-homologous RNA in HL-60 cultures and a decrease in this messenger RNA following the chemically induced differentiation of HL-60 cells. A nuclear transcription system isolated from HL-60 cells was used to investigate whether an alteration in the rate of transcription of the c-myc gene was associated with this decrease in m...
متن کاملDifferentiation antigens of HL-60 promyelocytes during induced maturation.
The human promyelocytic leukemic cell line HL-60 can be induced to mature monocytes and macrophages in vitro by lymphocyte-conditioned medium. We are reporting sequential changes in surface antigenic expressions, which are sensitive markers of the characteristic events in the process of cell differentiation. The promyelocyte membrane antigen, detected by a monoclonal antibody produced using HL-...
متن کاملDifferentiation Antigens of HL-60 Promyelocytes during Induced Maturation1
The human promyelocytic leukemic cell line HL-60 can be induced to mature monocytes and macrophages in vitro by lymphocyte-conditioned medium. We are reporting sequential changes in surface antigenic expressions, which are sensitive markers of the characteristic events in the process of cell differ entiation. The promyelocyte membrane antigen, detected by a monoclonal antibody produced using HL...
متن کاملGossypol-Induced Differentiation in Human Leukemia HL-60 Cells
The main treatment of leukemia is traditional radiochemotherapy, which is associated with serious side effects. In the past twenty years, differentiation was found as an important effective measure to treat leukemia with fewer side effects. Gossypol, a natural compound which has been used as an effective contraceptive drug, has been proposed to be a potent drug to treat leukemia, but the differ...
متن کاملRetinoic acid induced differentiation and commitment in HL-60 cells.
Human leukemic HL-60 cells are an established model for studies of differentiation induction. Retinoic acid (RA), 2 x 10(-6) M, was used to induce terminal differentiation, assayed as nitroblue tetrazol reduction (NBT) and expression of monocytic surface antigens, which were detected by monoclonal antibody Leu M3. In addition, transferrin receptor expression and the number of S + G2 + M-phase c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2009
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.57.536